Purpose: Anaphylaxis is an acute, life-threatening systemic reaction which should be treated by epinephrine. Patients who experienced anaphylaxis should be prescribed with epinephrine auto-injector for next crisis. The purpose of this study is to investigate the clinical features of pediatric anaphylaxis and usage of epinephrine within/after anaphylaxis. Methods: We performed a retrospective study about 94 anaphylaxis patients of in-patients, out-patients, and emergency department at Soonchunhyang University Hospital, Cheonan, Korea, who were under 15 years old, from Jan. 2013 through Dec. 2016. We reviewed their clinical features, doctor’s treatment methods, rate of follow up and prescribing epinephrine auto-injectors. Results: Causes of anaphylaxis were food (74.5%), drug 9(9.6%) and idiopathic (16.0%). The involved organs were cutaneous (90.4%), respiratory (85.1%), cardiovascular 23(24.5%), and gastrointestinal tract (14.9%). Patients were treated with systemic steroid 80(85.1%), anti-histamine 78(83.0%) and epinephrine 70(74.5%). 77 (81.9%) patients re-visited our pediatric allergy clinic and epinephrine auto-injectors were prescribed for 38 (40.4%) patients. None of patients used epinephrine auto-injector before arriving hospital. Conclusion: Physicians should make an effort to use epinephrine as the initial treatment for anaphylaxis, to prescribe epinephrine auto-injector and to give proper information about it.